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The Calorie Paradox: How Restricting Diet for Longevity May Be Compromising Health

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 By: Kristel Tjandra Introduction For decades, the "holy grail" of aging research has been a seemingly simple concept: eat less, live longer. Since the early 20th century, scientists have known that caloric restriction —reducing calorie intake without malnutrition—can significantly extend the lifespan of organisms ranging from yeast and worms to flies and mice. This phenomenon sparked a cultural and scientific movement, inspiring biohackers, Silicon Valley executives, and the general public to embrace intermittent fasting and severe calorie cuts in the hopes of dodging the ravages of time. The Calorie Paradox: How Restricting Diet for Longevity May Be Compromising Health However, a new wave of research emerging in 2026 suggests that the relationship between calories, aging, and health is far more complex—and potentially more perilous—than previously believed. A comprehensive study recently detailed in *Nature Metabolism* and highlighted by *Medical Xpress* indicates that whil...